The greatest battle lies within.
The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.
Tobey Maguire
Spider-Man / Peter Parker
Kirsten Dunst
Mary Jane Watson
James Franco
New Goblin / Harry Osborn
Thomas Haden Church
Sandman / Flint Marko
Topher Grace
Venom / Eddie Brock
Bryce Dallas Howard
Gwen Stacy
Rosemary Harris
May Parker
J.K. Simmons
J. Jonah Jameson
James Cromwell
Captain Stacy
Dylan Baker
Dr. Curt Connors
Theresa Russell
Emma Marko
Bill Nunn
Joseph 'Robbie' Robertson
